1483 Last date on which the Princes of the Tower were know to be alive: King Edward V (12), and his brother Prince Richard of Shrewsbury (9), sons of England's late King Edward IV, imprisoned by their uncle, who has become King Richard III. Never to be seen again.
Chancellor Thomas More investigated this years later. His conclusion relies primarily on circumstantial evidence and lays blame on Richard and his henchmen. Still in debate.
1500. the "Wedding of Blood" in Perugia, when Astorre Baglioni married Lavinia Colonna, and were promptly in a coup by cousin Grifonetto Baglioni.
Like many Italian cities, Perugia had a pretty homicidal domestic political life, with the great families indulging in frequent assassination, murder, and massacre. By the onset of the sixteenth century this struggle culminated in the primacy of the Baglioni, a family so blood-thirsty that when not slaughtering their enemies they did away with each other, culminating in the “Wedding of Blood” in July of 1500, when one faction of the family took advantage of the marriage of the head of a rival faction to massacre him and virtually all his close kin.
"These things must be done delicately-- or you hurt the spell." - The Wicked Witch of the West.
"We've got the torpedo damage temporarily shored up, the fires out and soon will have the ship back on an even keel. But I would suggest, sir, that if you have to take any more torpedoes, you take 'em on the starboard side." Pops Healy, DCA USS Lexington.