The premise is that you're playing as one of multiple Human factions, and you're all exploring & fighting your way across the Milky Way, so as to eventually return & reclaim the Sol system. It obviously has a bit of a Homeworld vibe.
Looks like one of the game's big selling points will be that stars & planets are "procedurally generated based on currently known data". Personally, that's not going to make it a must-buy, though it certainly sounds cool (if true).
Similarly, it also sounds like galaxy maps could be enormous: I can't imagine they'll actually consist of hundreds of billions of star systems -- I'm guessing that would almost certainly make even the most powerful gaming PC beg for mercy and/or commit suicide -- but who knows? Maybe the developer found a way around that problem.
The other major aspect of Stardust Exile I find interesting is that apparently it's intended to primarily be an MMORTS game, though exactly how that might work is currently unclear. Fortunately, however, it sounds as if the game will also release with a singleplayer mode when it goes int Early-Access (which looks like will happen later this year.
I'll be honest -- I'm not sure what to make of this one. I have a feeling it could end up not being my cup of tea...but it also could be, too. At the very least, I appreciate the dev is trying something a bit different with the genre. I have it added to my wishlist for the time being, if only so I can at least keep tabs on it. Whether it ends up being a game I'd enjoy or not, it looks like an interesting one to watch.